Service 05 / 18 · HVAC Engineering
Airflow Is Part of the Process.
HVAC is the system that holds a cleanroom in its classified state. Zoning, air change rates, HEPA filtration and AHU configuration are derived from room data sheets and the pressure cascade. Controls and monitoring are defined early, so BMS and EMS scope is clear before procurement.
Engineering phases
Where this service fits
07 / 09 phases in scope
- 01Feasibilitynot in scope
- 02ConceptIn scope
- 03Basic EngineeringIn scope
- 04Detailed EngineeringIn scope
- 05ProcurementIn scope
- 06ConstructionIn scope
- 07CommissioningIn scope
- 08ValidationIn scope
- 09Operationnot in scope
Scope
What the service covers
- 01Design criteria and HVAC zoning
- 02AHU configuration and HEPA filtration strategy
- 03Pressure cascade and air change rates
- 04Temperature and humidity control
- 05Heating and cooling load calculations
- 06Control philosophy and BMS interface
Method
From inputs to deliverables
INInputs
05 items- I01Room data sheets and cleanliness grades
- I02Cleanroom zoning and pressure strategy
- I03Process heat and moisture loads
- I04Site climate data
- I05Occupancy and operating hours
WORKActivities
06 items- W01Design criteria definition
- W02Load and airflow calculations
- W03AHU zoning and configuration
- W04Pressure cascade balancing
- W05Duct routing and terminal selection
- W06Control and monitoring definition
OUTDeliverables
09 items- D-05.01Design basis
- D-05.02Load calculations
- D-05.03Airflow calculations
- D-05.04Pressure diagram
- D-05.05AHU schedule
- D-05.06Duct layouts
- D-05.07Control philosophy
- D-05.08Equipment datasheets
- D-05.09BOQ
Technical detail
HVAC design topics
Contents · 07
01 / 07
Design criteria & environment
- Cleanliness grade per room
- Outdoor design conditions
- Product and process sensitivities
- Personnel comfort requirements
02 / 07
Air handling & filtration
- AHU zoning and segregation
- Fresh-air and recirculation strategy
- Filtration stages up to terminal HEPA
- Access for filter change and testing
03 / 07
Pressure cascades
- Pressure differentials between grades
- Airlock pressure regimes
- Containment versus product protection
- Door leakage and transfer air
04 / 07
Temperature, humidity & air changes
- Temperature and humidity set points and tolerances
- Dehumidification strategy
- Air change rates derived from grade and loads
- Recovery performance after interventions
05 / 07
Air distribution, return & exhaust
- Supply terminal arrangement
- Low-level return positions
- Dust extraction and process exhaust
- Duct routing and technical-space coordination
06 / 07
Controls & BMS interface
- Control philosophy and sequences of operation
- Alarm and interlock logic
- Separation of BMS and EMS functions
- Points lists for procurement
07 / 07
Energy optimization
- Heat recovery where product risk allows
- Reduced airflow modes outside production
- Efficient fan and coil selection
- Right-sizing to avoid oversized plant
Cleanrooms & HVAC
Airflow Is Part of the Process.
Explore how a cleanroom suite is organised: cleanliness grades, pressure relationships and the separate routes for people and materials.
01 / 04 — Z-GRAD
Grade / Zone
Each room is assigned a cleanliness grade from the process risk it carries.
- Grade B — process room
- Grade C — airlocks and wash room
- Grade D — gowning
- CNC — controlled, not classified corridor
Showing layer: Grade / Zone
Swipe to see the whole plan
Deliverables
Typical documents and outputs
- D-05.01Design basis
- D-05.02Load calculations
- D-05.03Airflow calculations
- D-05.04Pressure diagram
- D-05.05AHU schedule
- D-05.06Duct layouts
- D-05.07Control philosophy
- D-05.08Equipment datasheets
- D-05.09BOQ
Services
Related services
- 18
Facility Upgrades & Retrofit
Expansions, upgrades and retrofits engineered around the facility that is already running.
- 08
Qualification & Validation (CQV)
Documented evidence that facilities, utilities and equipment perform as intended.
Yes. Upgrades usually start with a review of the current zoning, pressure cascade and air handling against the process, followed by a phased design that keeps requalification in view.
Next step
Planning a pharmaceutical project?
Share the product type, the current stage and the main constraints. We will respond with a proposed scope and next steps.
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